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GJ
Verified CAS / Academic Author2 Decoded Studies

Prof. GAN Jingzheng

Fujian Medical University; Chinese Academy of Sciences

Research Publications & English Decoded Briefs

Showing 2 publications
SCIENCE CHINA Materials2026DOI: 10.1007/s40843-025-3503-9

Correction to: Mesoporous Bowl-Shaped Polydopamine Co-Loaded Temozolomide and Indocyanine Green for Synergistically Inhibiting Glioblastoma

This correction addresses an image misuse in the original publication (Sci China Mater, 2025, 68(6): 2095, DOI: 10.1007/s40843-025-3311-6). Specifically, a fluorescent image in Fig. 4d, depicting live/dead cells after treatment with MPDA@TMZ without laser irradiation, was erroneously presented. The corrected Fig. 4 is provided, and the authors confirm that the results and conclusions of the original paper remain unaffected. The correction ensures the integrity of the reported data, particularly the cell viability and apoptosis assays. The study focuses on mesoporous bowl-shaped polydopamine (MPDA) nanoparticles co-loaded with temozolomide (TMZ) and indocyanine green (ICG) for synergistic glioblastoma therapy. The corrected figure includes CLSM images of G422 cells after incubation with various formulations (ICG, sPDA@ICG, mPDA@ICG, MPDA@ICG), cell viability curves, quantitative fluorescence intensity, live/dead staining, and apoptosis quantification. Statistical significance is denoted as ****p < 0.01. The correction maintains the scientific validity of the findings, which demonstrate the potential of MPDA-based nanoplatforms for combined chemo-photothermal therapy.

SCIENCE CHINA Materials2025DOI: 10.1007/s40843-025-3311-6

Mesoporous bowl-shaped polydopamine co-loaded temozolomide and indocyanine green for synergistically inhibiting glioblastoma

Glioblastoma (GBM) remains a lethal malignancy with a five-year survival rate of 6%, and standard temozolomide (TMZ) chemotherapy is constrained by short plasma half-life and insufficient tumor accumulation. This study reports a mesoporous polydopamine nanocarrier with a bowl-like morphology co-loaded with indocyanine green (ICG) and TMZ (MPDA@ICG/TMZ) for combined photothermal therapy (PTT) and chemotherapy. The nanoplatform exhibits a photothermal conversion efficiency of 43.88% under 808 nm laser irradiation. The bowl-shaped morphology significantly enhances cellular uptake relative to conventional mesoporous nanospheres. Hyperthermia amplifies TMZ cytotoxicity, reducing cell survival to 17.2% in vitro. In GBM-bearing nude Balb/C mice, MPDA@ICG/TMZ accumulates in tumors via the enhanced permeability and retention (EPR) effect, visualized by second near-infrared window (1000–1700 nm) fluorescence imaging. The combined treatment achieves complete tumor cell eradication in vitro and in vivo under 808 nm laser illumination. These results establish MPDA@ICG/TMZ as a potent nanoplatform for synergistic chemotherapy and PTT, offering a promising direction for GBM treatment.