Key Takeaways & Executive Findings
- •• • The correction does not alter the original conclusions; the reported synergistic inhibition of glioblastoma by MPDA@TMZ/ICG remains valid, with statistical significance at ****p < 0.01. • • The corrected Fig. 4 includes quantitative cell viability data for MPDA@ICG/TMZ and MPDA@ICG/TMZ+L across various concentrations, confirming dose-dependent therapeutic efficacy. • • Live/dead cell fluorescence imaging (Fig. 4d) now accurately represents the effects of MPDA@TMZ without laser, ensuring reproducibility of the experimental results. • • The study employs G422 glioblastoma cells, demonstrating the nanoplatform's potential for targeted chemo-photothermal therapy, with implications for clinical translation in glioblastoma treatment.
Abstract
This correction addresses an image misuse in the original publication (Sci China Mater, 2025, 68(6): 2095, DOI: 10.1007/s40843-025-3311-6). Specifically, a fluorescent image in Fig. 4d, depicting live/dead cells after treatment with MPDA@TMZ without laser irradiation, was erroneously presented. The corrected Fig. 4 is provided, and the authors confirm that the results and conclusions of the original paper remain unaffected. The correction ensures the integrity of the reported data, particularly the cell viability and apoptosis assays. The study focuses on mesoporous bowl-shaped polydopamine (MPDA) nanoparticles co-loaded with temozolomide (TMZ) and indocyanine green (ICG) for synergistic glioblastoma therapy. The corrected figure includes CLSM images of G422 cells after incubation with various formulations (ICG, sPDA@ICG, mPDA@ICG, MPDA@ICG), cell viability curves, quantitative fluorescence intensity, live/dead staining, and apoptosis quantification. Statistical significance is denoted as ****p < 0.01. The correction maintains the scientific validity of the findings, which demonstrate the potential of MPDA-based nanoplatforms for combined chemo-photothermal therapy.
1. Introduction
Glioblastoma multiforme (GBM) remains one of the most intractable malignancies, with a median survival of less than 15 months despite aggressive standard-of-care therapies. The blood-brain barrier (BBB) and tumor heterogeneity severely limit the efficacy of conventional chemotherapeutics like temozolomide (TMZ), while photothermal therapy (PTT) suffers from poor tumor specificity and inadequate tissue penetration. Existing nanocarriers often exhibit suboptimal drug loading, premature release, and insufficient photothermal conversion, hindering synergistic chemo-photothermal strategies.
This study addresses these bottlenecks by engineering mesoporous bowl-shaped polydopamine (MPDA) nanoparticles that co-deliver TMZ and indocyanine green (ICG). The unique bowl morphology enhances cellular uptake and drug loading, while polydopamine's photothermal properties enable near-infrared (NIR) triggered therapy. The correction ensures the accuracy of the reported live/dead cell imaging, reinforcing the reliability of the data that demonstrate synergistic inhibition of GBM cells. This nanoplatform offers a promising approach to overcome the limitations of current GBM therapies, potentially improving patient outcomes.
Loading authentic research manuscript (Pages 1–5)...
Guangwei Zheng, Lei Ding, Jingzheng Gan, Tingting Li, Xiaolong Liu, Xiaolong Zhang, Peiyuan Wang, De Wei (2026). Correction to: Mesoporous Bowl-Shaped Polydopamine Co-Loaded Temozolomide and Indocyanine Green for Synergistically Inhibiting Glioblastoma. SCIENCE CHINA Materials. https://doi.org/10.1007/s40843-025-3503-9
Research & Educational Purpose Only: The translations, structured abstracts, analytical annotations, and data reports provided by SinoGreenTechare intended exclusively for academic research, internal corporate R&D, and educational benchmarking. They do not constitute formal engineering, chemical safety, legal, or professional advice.
Copyright & Intellectual Property Notice: Original copyright of the underlying source articles and experimental data remains with the respective authors, institutions, and original publishing journals. SinoGreenTech claims intellectual property only over its proprietary translations, analytical syntheses, and AEO structured enhancements in accordance with international fair use and academic citation principles.
Frequently Asked Questions
What is the significance of the corrected image in Fig. 4d, and how does it impact the interpretation of the therapeutic efficacy?
The corrected image in Fig. 4d accurately represents the live/dead cell staining after MPDA@TMZ treatment without laser irradiation. This correction ensures that the observed cell death is not erroneously attributed to photothermal effects, thereby validating the intrinsic chemotherapeutic action of TMZ. The original conclusions remain unchanged, confirming that MPDA@TMZ alone exhibits cytotoxic effects, while combination with laser (MPDA@ICG/TMZ+L) enhances efficacy via synergistic chemo-photothermal action, as supported by quantitative apoptosis assays (****p < 0.01).
How do the bowl-shaped MPDA nanoparticles improve drug loading and photothermal conversion compared to spherical counterparts?
The bowl-shaped morphology of MPDA provides a larger surface area and cavity volume relative to spherical polydopamine nanoparticles (sPDA), facilitating higher drug loading of TMZ and ICG. Additionally, the anisotropic structure enhances light absorption and scattering, improving photothermal conversion efficiency under NIR irradiation. These properties are critical for achieving synergistic therapeutic effects at lower drug doses, potentially reducing systemic toxicity.
What are the key experimental parameters (e.g., concentrations, laser conditions) used in the cell viability and apoptosis assays?
The study utilized G422 glioblastoma cells incubated with various concentrations of MPDA@ICG/TMZ and MPDA@ICG/TMZ+L. While specific concentrations are not detailed in the correction, the cell viability curves (Fig. 4b) indicate dose-dependent responses. Laser treatment conditions (likely 808 nm NIR) were applied for the photothermal groups. Statistical significance was denoted as ****p < 0.01, indicating high confidence in the observed differences.
How does this correction affect the reproducibility and credibility of the original study for clinical translation?
The correction addresses a critical image error, ensuring that the reported live/dead cell data are accurate. This enhances the reproducibility of the experimental results, as other researchers can now rely on the corrected figure for validation. The unchanged conclusions reinforce the robustness of the MPDA-based nanoplatform, supporting its potential for further preclinical development and eventual clinical translation in glioblastoma therapy.
What are the next steps required to advance this MPDA@TMZ/ICG system toward in vivo evaluation and clinical trials?
Future studies should focus on comprehensive in vivo pharmacokinetics, biodistribution, and therapeutic efficacy in orthotopic glioblastoma mouse models. Additionally, long-term toxicity and biocompatibility assessments are essential. Scale-up synthesis of MPDA nanoparticles with consistent quality and batch-to-batch reproducibility must be established. Finally, optimization of laser parameters (e.g., power density, irradiation time) and combination regimens with standard of care will be critical for clinical translation.
Related Chinese Research & Cross-Citations
Ammonium Vanadate Cathodes in Aqueous Zinc-Ion Batteries: Design Strategies and Research Progress
Aqueous zinc-ion batteries (AZIBs) offer a compelling combination of high safety, environmental compatibility, and abundant zinc resources, positioning them as viable candidates for grid-scale energy storage. Their practical deployment, however, is constrained by cathode materials that suffer from structural degradation, sluggish Zn2+ diffusion, and inadequate electronic conductivity. Ammonium vanadates (AVOs) have emerged as high-performance cathodes owing to their layered or tunneled frameworks, which accommodate reversible Zn2+ (de)intercalation with diffusion coefficients superior to conventional vanadium oxides. This review systematically examines recent advances in AVO cathodes for AZIBs, correlating morphological variations—including nanowires, nanobelts, and microflowers—with electrochemical characteristics. The analysis establishes structure–performance relationships that govern capacity retention, rate capability, and cycling stability. Key optimization strategies are critically assessed: defect engineering to enhance electronic conductivity and active site density, interlayer spacing modulation via pre-intercalated cations or structural water to facilitate Zn2+ transport, and composite construction with conductive carbonaceous or polymeric matrices to mitigate dissolution and improve mechanical integrity. Despite these advances, challenges persist in achieving long-term cycling stability (>10,000 cycles) and high areal mass loading (>10 mg cm-2) required for commercial viability. The review concludes by outlining future research directions, including operando characterization of degradation mechanisms and scalable synthesis routes for AVO cathodes in practical AZIB configurations.
Microenvironment-responsive therapeutic platforms: Innovations for spinal cord injury repair
Spinal cord injury (SCI) remains a formidable clinical challenge due to the complex, dynamic lesion microenvironment that impedes axonal regeneration and functional recovery. This highlight examines a microenvironment-responsive therapeutic platform integrating microneedle delivery, ferroptosis modulation, and hydrogen therapy. The platform leverages the pathological hallmarks of SCI—oxidative stress, iron dyshomeostasis, and lipid peroxidation—to achieve spatiotemporally controlled cargo release. By combining microneedle arrays for minimally invasive intraparenchymal administration with hydrogen-releasing biomaterials, the system addresses the dual bottlenecks of poor drug penetration across the blood-spinal cord barrier and insufficient neutralization of reactive oxygen species. Ferroptosis inhibition is achieved through iron chelation and glutathione peroxidase 4 (GPX4) stabilization, while hydrogen gas scavenges hydroxyl radicals and peroxynitrite. This multimodal strategy attenuates secondary injury cascades, reduces glial scar formation, and promotes neural stem cell differentiation. The work is supported by the National Natural Science Foundation of China (82574518) and the Talent Cultivation Project of Paring Academicians with Young Talents in higher education institutions in Zhejiang. The authors declare no conflict of interest. This highlight underscores the translational potential of microenvironment-responsive platforms for SCI repair, emphasizing the need for rigorous preclinical validation and scalable manufacturing.
Dual-Site Adsorption over Phosphorus-Doped Copper Oxide for Efficient CO2 Electroreduction to Ethylene
Electroreduction of CO2 to ethylene offers a promising route for renewable electricity storage, yet achieving high ethylene selectivity at industrial current densities remains challenging due to the large energy barrier for C–C coupling. Here, we report a “MOF-assisted in situ doping” strategy to introduce the oxophilic nonmetal phosphorus (P) into the copper oxide (CuO) lattice, constructing a localized Cu–P dual-site adsorption configuration for the key *OCCHO intermediate. The optimized catalyst delivers an impressive Faradaic efficiency of 64.6% for ethylene with a partial current density of 646 mA cm-2. Comprehensive structural characterizations demonstrate that P mainly occupies Cu sites, generating abundant lattice defects and oxygen vacancies. In situ synchrotron infrared spectroscopy and theoretical calculations reveal that P doping modulates the electronic structure of Cu, optimizes the binding energies of *CO and *CHO, and stabilizes *OCCHO via P–O/Cu–C dual-site adsorption, thereby significantly lowering the asymmetric C-C coupling energy barrier to 0.74 eV. This work highlights a dual-site microenvironment regulation strategy for CO2-to-ethylene electroreduction.
Hydrophilic Single-Atom Interface Unlocks Low-Potential CO Removal on Pt in PEMFCs
Proton exchange membrane fuel cells (PEMFCs) fed with reformate hydrogen suffer severe anode poisoning by trace CO, necessitating high CO electrooxidation potentials that degrade performance and durability. This work introduces a Pt@CrSA-N-C anode catalyst featuring a hydrophilic Cr single-atom interface that simultaneously weakens CO adsorption on Pt via electronic regulation and promotes water activation, thereby lowering the CO oxidation onset potential to approximately 0.13 V vs. RHE. The onset potential was determined by two independent methods: the first potential at which the background-corrected current exceeds 0 mA cm-2 during CO oxidation reaction tests in a three-electrode system, and the potential at which the forward scan current exceeds the N2 background current in CO-stripping voltammetry. The catalyst achieves a maximum power density under 100 ppm CO that surpasses reported advanced catalysts, as compiled in Table S5. Structural, spectroscopic, and electrochemical characterizations collectively establish a coherent rationale for the hydrophilic single-atom interface strategy. This approach addresses the longstanding trade-off between CO tolerance and Pt utilization, offering a viable route for low-potential CO removal in practical PEMFC anodes.
An Ionoelastomer-Based Bioinspired Wearable Electronics with Tele-Perception and Tactile Sensation for Machine Learning-Assisted Rehabilitation Management
Comprehensive assessment of rehabilitation efficiency is essential for designing appropriate training programs for better musculoskeletal functional recovery. Existing contact-receptor-dependent rehabilitation assessment systems mostly focus on assessing the restoration of muscle function by evaluating grip strength or joint flexion angle; however, parameters reflecting neuromuscular synergistic function are always overlooked. Herein, we develop an ionoelastomer-based soft artificial electroreceptor (SAER) that integrates tele-perception and tactile sensation to track the rehabilitation process, collecting signals related to approaching speed and grip strength sequentially. The SAER uses polyurethane ionoelastomer incorporated with quasi-solid conductive salt as the electric field receptor, and is integrated on a rehabilitation-training ball after assembly to establish an untethered detection device; this enables the remote capture of hand approaching parameter within a 9 cm range, followed by the quantification of grip strength when contacting and grasping. Furthermore, a data-driven assessment system is established by integrating machine learning, which accurately classifies rehabilitation efficiency into six levels; it supports for rehabilitation evaluation and training programs adjustment. Overall, the SAER-based rehabilitation management system establishes a paradigm that synergistically evaluating parameters corresponding to neuromuscular functional restoration and holds strong potential for home-based active rehabilitation for minimizing dependence on frequent clinical supervision.
Microwave-Absorbing Materials with Strong Environmental Adaptability for Corrosion Protection, Anti-Icing, and Thermal Management
Microwave-absorbing materials (MAMs) deployed on naval vessels, aerospace vehicles, and critical electronic systems face coupled electromagnetic, marine salt-spray corrosion, and extreme-temperature loads that legacy single-function absorbers cannot withstand. This review consolidates progress on three environmentally adaptive MAM classes: corrosion-protective, anti-icing, and thermal-management absorbers. The electromagnetic loss and impedance-matching fundamentals are first established, then the synergistic mechanisms, design strategies, and characterization protocols for each class are examined against representative material systems and their measured performance. The analysis identifies a shared design logic—multiscale hierarchical architecture, interfacial polarization engineering, and multifunctional phase integration—while distinguishing the divergent protection mechanisms: barrier and passivation effects for corrosion, surface-energy and latent-heat regulation for anti-icing, and phonon–electron transport decoupling for thermal management. Persistent bottlenecks include the trade-off between impedance matching and protective-layer density, the absence of standardized coupled-field test protocols, and the scarcity of long-term salt-spray and thermal-cycling durability data. Future directions are delineated: intelligent self-adaptive absorbers, multiphysics-coupled simulation frameworks, and environmentally benign multifunctional integration. The review provides a theoretical and technical basis for the design, construction, and engineering scale-up of next-generation high-performance absorbers for aerospace, electronic, and marine equipment.