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QJ
Verified CAS / Academic Author2 Decoded Studies

Prof. Quan Jiang

East China University of Science and Technology

Research Publications & English Decoded Briefs

Showing 2 publications
SCIENCE CHINA Materials2026DOI: 10.1007/s40843-025-3874-1

Thriving In-Memory Computing and Neuromorphic Applications of Ferroelectric-Based Devices

The rapid expansion of artificial intelligence (AI) model sizes to trillions of parameters has intensified the demand for computational paradigms that overcome the von Neumann bottleneck. Emerging memory technologies, while advancing, fall short of meeting the massive requirements of large-scale models. Ferroelectric materials, with their continuous tunability of domain patterns, offer a promising route to emulate synaptic weights in biological learning. This review systematically examines four fundamental ferroelectric-based device architectures: ferroelectric capacitors, ferroelectric field-effect transistors (FeFETs), ferroelectric tunnel junctions (FTJs), and ferroelectric domain wall memories. We analyze their latest progress, application domains, and inherent advantages, while critically assessing the challenges impeding their commercialization. Key issues include scalability, endurance, retention, and integration with CMOS technology. We also highlight optimization strategies for material and device performance, array-level design, and neuromorphic computing architectures. Future research directions are proposed, emphasizing the expansion of novel applications and the realization of energy-efficient, high-density in-memory computing systems. This review provides a comprehensive framework for researchers and engineers aiming to harness ferroelectric devices for next-generation computing.

SCIENCE CHINA Materials2025DOI: 10.1007/s40843-025-3393-8

Dual-Locked SO2/Nanozyme Delivery Nanoplatform for Programmed Synergistic Gas/Chemodynamic Anticancer Therapy

SO2 gas therapy offers sustained assistance for augmenting the efficacy of ROS-based modalities due to its powerful tumor microenvironment-reversing capabilities. However, inefficient delivery and insufficient generation of SO2 have greatly limited the efficacy of SO2 therapy. Herein, we designed a programmed-responsive SO2/nanozyme synergistic therapeutic nanomedicine based on the polypeptide-type copolymer of poly(ethylene glycol)-b-poly(L-lysine) (PEG-b-PLL). By taking advantage of the abundant amine groups on the PLL blocks, a dual-locked SO2 releasing system was fabricated by grafting SO2 prodrug onto the PLL blocks through GSH-responsive covalent bonds and crosslinking the remaining amine groups with disulfide-connectors to form an outer stimulation-responsive shell. Such a dual encapsulation effectively prevented the premature release of SO2 in normal cells and guaranteed its timely and sustained release, making the SO2 therapeutic processes finely coordinate with the catalytic processes of nanozymes loaded in the micellar core. The well-matching of SO2 and nanozyme resulted in the efficacious remodeling of the tumor redox microenvironment, thus significantly enhancing the overall efficacy of chemodynamic therapy (CDT). This optimized multimodal cooperation strategy provides delicate control for improving the synergistic therapeutic efficiencies, which is anticipated to advance the ROS-based cancer treatments.