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LJ
Verified CAS / Academic Author2 Decoded Studies

Prof. LIANG Jiaheng

Tsinghua University

Research Publications & English Decoded Briefs

Showing 2 publications
SCIENCE CHINA Materials2026DOI: 10.1007/s40843-025-3652-2

Bio-inspired self-sensing suction cups for stable dynamic grasping

Existing robotic end-effector gripping technologies often encounter challenges such as poor adaptability to environmental changes, incomplete deformation sensing, and insufficient adhesion stability, which can compromise operational safety and reliability. Here, we present the bio-inspired self-sensing suction cup, in which the core self-sensing capability is achieved by combining high-performance, laser-induced graphene/Ag NWs flexible sensors with a Wheatstone bridge design. The flexible sensors provide high sensitivity, while the Wheatstone bridge circuit enables accurate and stable detection of deformation during the gripping process. Integrated into the octopus-inspired suction cup, this system allows for real-time monitoring of deformation and adsorption stability. The self-sensing suction cup demonstrates good performance across a 0–25 kPa negative pressure range, with outstanding linearity (R2 = 0.993) and high sensitivity (GF = 10.436 kPa−1). Experimental results confirm that the suction cup can achieve stable adsorption under varying loads and enable real-time monitoring of the suction cup status during the gripping process. This design provides a promising solution for intelligent gripping systems, logistics, and object recognition in challenging environments.

SCIENCE CHINA Materials2025DOI: 10.1007/s40843-025-3477-2

Eliminate Drug-Resistant Bacterial Infection and Accelerate Cutaneous Wound Repair by Antimicrobial, Angiogenic, and Immunomodulating Microneedles

Bacterial infection disrupts wound repair through sustained inflammatory responses and impaired angiogenesis, while antibiotic resistance severely limits conventional therapies. This study reports a dissolving microneedle (MN) system for transdermal delivery of ε-poly-L-lysine (EPL)/hyaluronic acid (HA) nanoparticles (EH NPs) to eliminate methicillin-resistant Staphylococcus aureus (MRSA) and accelerate wound healing. Electrostatic co-assembly of EPL and HA yields nanoparticles with enhanced cellular phagocytosis, enabling combined antimicrobial, angiogenic, and anti-inflammatory activities. In vitro, the MN system eradicates >99.9% of MRSA, upregulates endogenous nitric oxide release and CD31 expression in human vascular endothelial cells, and promotes macrophage polarization from M1 to M2 phenotype. In a drug-resistant bacteria-infected skin wound mouse model, the MN system significantly enhances granulation tissue formation and collagen deposition by promoting angiogenesis and reducing inflammation, thereby accelerating wound closure. This multifunctional microneedle platform addresses the limitations of conventional dressings by overcoming the skin barrier for efficient transdermal delivery of synergistic bioactive nanoparticles, offering a promising clinical strategy for infected wound management.