Environmental Chemistry•2026•DOI: 10.7524/j.issn.0254-6108.2024100805
A fluorescent metal-organic framework (MOF), PCN-128, was synthesized via a solvothermal method using zirconium tetrachloride (ZrCl4) as the metal source and tetrakis[4-(4'-carboxyphenyl)phenyl]ethylene (H4ETTC) as the organic linker. The resulting material exhibited regular morphology, high crystallinity, strong luminescence, and good stability. PCN-128 was employed as a fluorescent probe for the trace detection of malachite green (MG), a banned veterinary drug, in aquaculture water and freshwater fish tissue. The probe demonstrated exceptional selectivity toward MG among 13 veterinary drugs and robust anti-interference performance against 16 anions, 16 cations, and 12 additional veterinary drugs. The method achieved a broad linear detection range from 0.0 to 7.0 μmol·L−1 with a limit of detection (LOD) of 2.73 nmol·L−1. Spike-and-recovery experiments in three aquaculture water samples and one freshwater fish sample yielded recoveries between 89.80% and 113.7%, with relative standard deviations (RSD) not exceeding 2.59%. These results confirm that the developed method is accurate, reliable, and suitable for routine monitoring of MG residues in aquaculture water and aquatic products, addressing a critical gap in food safety surveillance.
SCIENCE CHINA Materials•2026•DOI: 10.1007/s40843-025-4027-0
Microneedle (MN)-based transdermal delivery systems enhance skin permeability by creating microscale conduits through the stratum corneum, enabling controlled and sustained release of therapeutics. Nevertheless, conventional MN designs predominantly rely on passive diffusion, resulting in shallow drug penetration depth and limited spatial distribution range, which significantly restricts their therapeutic efficacy in complex biological environments. Emerging advancements have integrated gas therapy into MN platforms to overcome these limitations. The released therapeutic gases facilitate deeper drug penetration via propulsion and also exhibit inherent bioactivity, contributing to synergistic treatment outcomes. This review summarizes the mechanisms, design strategies, and applications of gas-releasing MN systems, while highlighting key scientific and translational challenges, including the precise regulation of gas release, the development of multi-gas synergistic systems, the extension to deep-tissue therapy, and the assurance of biosafety. Future directions emphasize the construction of intelligent, stimuli-responsive MNs, the integration of interdisciplinary technologies to enhance delivery depth, and the establishment of standardized, scalable manufacturing frameworks. Collectively, this work aims to advance gas-releasing MN technology toward precise, efficient, and controllable therapeutic applications, bridging the gap between laboratory research and clinical translation.