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Prof. GUO Xueping

College of Environmental Science and Engineering, Tongji University, Shanghai, 200092, China

Co-Affiliations:Key Laboratory of Yangtze River Water Environment, Ministry of Education, College of Environmental Science and Engineering, Tongji University

Research Publications & English Decoded Briefs

Showing 2 publications
Environmental Chemistry•2026•DOI: 10.7524/j.issn.0254-6108.2025101101

Transgenerational Toxicity of Acetamiprid in Caenorhabditis elegans

Acetamiprid, a representative neonicotinoid insecticide, persists in soil and water, posing ecological risks. This study evaluated its transgenerational toxicity in Caenorhabditis elegans exposed to 1, 10, and 100 μg·L−1. Direct exposure (F0) caused neurobehavioral abnormalities, with head swing frequency significantly increased by 23.86% even at 1.0 μg·L−1, correlating with disrupted acetylcholinesterase and γ-aminobutyric acid. Reproduction, development, metabolism, and intestinal barrier were impaired, with reactive oxygen species elevated by 30.42%–48.28%, indicating oxidative stress as a mechanism. Effects transmitted to unexposed T1–T3 generations: at 1.0 μg·L−1, body width inhibition persisted to T2; fat accumulation and intestinal permeability effects intensified with concentration. Among oxidative stress biomarkers, superoxide dismutase showed highest sensitivity and transgenerational persistence. This study reveals multidimensional transgenerational toxicity, informing soil ecological risk assessment of neonicotinoids.

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Environmental Chemistry•2026•DOI: 10.7524/j.issn.0254-6108.2025102501

Effects and Mechanisms of Non-Antibiotic Emerging Contaminants on Fish Gut Microbiota

Non-antibiotic emerging contaminants (ECs) pose a growing threat to aquatic organisms, particularly fish, yet their impact on gut microbiota remains inadequately characterized. This systematic review synthesizes current evidence on the effects and mechanisms of non-antibiotic pharmaceuticals, pesticides, per- and polyfluoroalkyl substances (PFAS), nanomaterials, and microplastics on fish gut microbiota. Exposure to these ECs directly alters microbial composition and diversity, while indirectly disrupting host metabolism and immune function, leading to significant health impairments. Notably, EC exposure induces dysregulation of key factors such as lipopolysaccharide (LPS), compromising intestinal barrier integrity. Concurrently, gut microbiota can metabolically transform certain ECs into derivatives, establishing a complex pollutant-microbiota-host interaction network. The gut microbiota mediates EC-induced neurotoxicity, immune dysfunction, and metabolic disorders through signaling pathways such as TLR/NF-κB and metabolic homeostasis regulation. Current research predominantly addresses short-term exposure effects, leaving long-term low-dose impacts and transgenerational mechanisms poorly understood. Future investigations should employ multi-generational exposure and microbiota transplantation to elucidate gut microbiota-mediated toxicity mechanisms under non-antibiotic EC stress. This review underscores the urgent need for comprehensive risk assessment and regulatory frameworks targeting non-antibiotic ECs in aquatic environments.

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Prof. GUO Xueping | Publications & Academic Profile | SinoGreenTech | SinoGreenTech