Strain-Resilient Bioelectronics Enabled by Coupled Material-Circuit Design

• • SIRES maintains stable electrochemical reactivity under large mechanical strain by coupling a liquid-metal elastomeric conductor with a Randles circuit model that explicitly accounts for strain-dependent charge-transfer resistance; this eliminates the baseline drift that plagues percolation-based stretchable electrodes above 50% strain. • • The platform achieves high-fidelity multiplexed molecular monitoring on dynamic biological surfaces (skin, stomach, intestine), where conventional electrochemical sensors exhibit signal distortion due to active-area fluctuation and disrupted conductive pathways; this enables continuous metabolite tracking during organ deformation. • • The material-circuit co-design strategy preserves interfacial charge-transfer kinetics during deformation, directly addressing the degradation mechanism that limits existing stretchable biointerfaces to static or low-strain conditions; this expands the operational envelope for implantable diagnostics. • • The work provides a universal design framework for soft bioelectronics, with translation potential contingent on resolving fabrication scalability and encapsulation reliability; current limitations in system integration remain the primary barrier to clinical adoption.