• • Optimal light attenuation of 1.54 ± 0.04 dB/cm achieved via template-assisted fabrication, ensuring structural homogeneity and minimal signal loss during assembly and splicing; this low attenuation is critical for long-term implantable sensing where signal-to-noise ratio directly impacts diagnostic reliability.
• • Imine bonding enables dynamic covalent reconfiguration, allowing programmable assembly of distinct functional phases for stress, temperature, and pH sensing; this addresses the industrial bottleneck of multi-analyte decoupling in a single fiber, reducing the need for multiple independent sensors and lowering clinical integration complexity.
• • Multi-responsive sensing capability demonstrated for stress, temperature, and pH, with decoupling of overlapping signals; this is essential for in vivo applications where physiological fluctuations (e.g., pH 6.8–7.4, temperature 36–40 °C) can confound single-parameter readings, enabling more accurate real-time monitoring.
• • Template-assisted method ensures structural homogeneity among functional units, resulting in uniform structure after assembly and splicing; this reproducibility is vital for scalable manufacturing, as inconsistent fiber geometry would lead to variable attenuation and unreliable sensor performance in mass production.