Recent Advances in Two-Dimensional Nanomaterials for the Treatment of Liver Fibrosis

• • 2D nanomaterials (graphene, TMDs, BPNSs, MXenes, LDHs) exhibit ultrahigh surface area and tunable surface chemistry, enabling multifunctional antifibrotic interventions targeting HSC activation, ECM deposition, and oxidative stress. • • The review cites 2025 references (e.g., Nanoscale, 2025, 17: 1616–1643) indicating recent progress in 2D material synthesis and biomedical applications, with specific focus on liver fibrosis. • • Challenges remain in long-term biosafety, precise functionalization for tissue-specific targeting, and scalable synthetic methods, as highlighted in the abstract. • • The paper systematically reviews mechanisms of action, including modulation of HSCs and inhibition of ECM deposition, providing a framework for clinical translation.