• • Nutrient deprivation strategies, such as glucose oxidase (GOx)-mediated glucose depletion, can induce starvation by reducing intratumoral glucose levels to below 0.5 mM, effectively suppressing ATP production and cancer cell proliferation (reference 290).
• • Combination of ST with ferroptosis inducers, e.g., glutathione-depleting nanoparticles, achieves synergistic antitumor efficacy by simultaneously blocking nutrient supply and enhancing lipid peroxidation, with a tumor inhibition rate exceeding 85% in murine models (reference 283).
• • Gas therapy synergized with ST, using CO-releasing nanocatalysts, demonstrates controlled release under tumor microenvironment conditions (pH 6.5, H2O2 100 μM), leading to mitochondrial damage and a 3.2-fold increase in apoptosis compared to ST alone (reference 279).
• • Electrodynamic therapy combined with ST, employing porous Pt nanospheres with GOx, generates reactive oxygen species under an alternating magnetic field, achieving a complete tumor regression in 60% of treated mice (reference 290).