• • NiHCF core retains 95% of its redox signal after 5000 electrochemical cycles, a degradation rate of ~0.001% per cycle, directly addressing the operational lifespan limitation of implantable sensors in complex biological fluids.
• • Citrate-assisted synthesis yields uniform NiHCF nanocubes with low lattice strain, enabling consistent electrochemical signaling; DFT-verified monomer selection ensures precise molecular complementarity within the MIP cavity, improving selectivity for target biomarkers.
• • Formulation of MIP/NiHCF nanoparticles into inkjet-printable ink enables scalable, additive manufacturing, reducing labor-intensive multi-step processes and enhancing reproducibility and production efficiency for mass production.
• • The dual-functional architecture combines selective target capture (MIP shell) with stabilized electrochemical signaling (NiHCF core), achieving a balance between high selectivity and stability that conventional enzyme-based or unstable redox probes fail to maintain under physiological conditions.