• • DJP achieves programmable adhesion with a 2.81-fold enhancement in interfacial stability through transition from noncovalent to covalent bonding, enabling repositioning within a short time to correct misplacement during surgery.
• • The micron-scale poly(sulfobetaine methacrylamide) brush layer provides hydration lubrication with a coefficient of friction of 0.06, effectively reducing frictional stimuli to injured tissue, a critical factor in adhesion formation.
• • In a rat model, DJP significantly reduced deposited collagen between abdominal wall and cecum compared to commercial barriers, demonstrating efficacy in preventing postoperative abdominal adhesion and promoting tissue healing.
• • The catechol-containing copolymer confers antioxidative and anti-inflammatory properties, addressing the inflammatory component of adhesion pathogenesis, as validated in vitro.