PANoptosis-Driven Immunogenic Cell Death by a Single NIR Laser-Triggered Nanoplatform for Cancer Phototherapy

• • The m-ITIC NPs achieve a singlet oxygen quantum yield of 56.8% and photothermal conversion efficiency of 27.4% under a single NIR laser, enabling dual-modal PDT/PTT with high therapeutic efficacy. • • The nanoplatform induces PANoptosis, a coordinated cell death program integrating pyroptosis, apoptosis, and necroptosis, which amplifies immunogenic cell death (ICD) and enhances antitumor immune responses. • • In vivo studies demonstrate significant tumor growth inhibition and prevention of lung metastasis, with robust dendritic cell activation, M1 macrophage polarization, elevated CD8+ T cell infiltration, and suppression of Treg cells. • • Therapeutic efficacy was validated in patient-derived tumor organoids, indicating strong translational potential for clinical cancer phototherapy.