• • The fiber probe integrates decoupled modules for photothermal heating and optical thermometry, enabling real-time temperature sensing with a resolution of 0.5°C under NIR laser irradiation, which is critical for precise thermal dose control in clinical hyperthermia.
• • Lanthanide-doped nanoparticles generate reactive oxygen species (ROS) under 980 nm NIR excitation without exogenous photosensitizers, achieving a ROS quantum yield of 12% as measured by DPBF assay, thereby eliminating the need for potentially toxic photosensitizers in photodynamic therapy.
• • The all-optical fiber system achieves synergistic photothermal and photodynamic therapy, with in vitro tumor cell viability reduced to 8% after 10 minutes of combined treatment, compared to 45% for photothermal therapy alone, demonstrating enhanced therapeutic efficacy.
• • The probe maintains stable performance over 50 heating-cooling cycles with less than 2% variation in temperature readout, ensuring reliability for repeated clinical use and long-term monitoring.