Intercalation-Engineered MOF for Ultrasensitive Ratiometric Fluorescent Sensing of Enoxacin

• • HSB-W18-MS achieves an LOD of 5.62 nM for enoxacin in aqueous solution, with response kinetics under 30 seconds, enabling real-time monitoring of fluoroquinolone contamination at trace levels. • • The sensor maintains luminescence intensity and aqueous dispersibility for over one month, ensuring long-term operational stability for field deployment without frequent recalibration. • • In complex environmental matrices, the sensor quantifies enoxacin with LODs of 18.32 nM in tap water and 29.87 nM in river water, demonstrating practical utility for on-site water quality assessment. • • The intercalation-engineered MOF design, confirmed by single-crystal X-ray diffraction, provides atomic-level structural insight, enabling rational optimization of sensing performance and selectivity.