Injectable Hydrogel with Photothermal Antibacterial Properties for Accelerating Infected Wound Healing

• • HPAu gel achieved near-complete eradication of Staphylococcus aureus in infected wounds under NIR irradiation, with IL-10 anti-inflammatory marker area reaching 12.88‰ versus <2‰ in Blank, demonstrating potent immunomodulation and infection control. • • Photothermal therapy reduced TNF-α pro-inflammatory fluorescence area significantly (p<0.05) compared to Blank and HPAu (NIR-) groups, indicating effective mitigation of infection-induced inflammation. • • HPAu (NIR+) group exhibited abundant elongated blood vessels with higher CD31 and α-SMA expression, indicating enhanced angiogenesis and vascular maturation, critical for oxygen/nutrient delivery and tissue regeneration. • • The hydrogel's injectable and self-healing properties, derived from dynamic phenylboronic acid ester bonds, allow conformal filling of irregular wound cavities, addressing a key limitation of traditional dressings.