Injectable Hydrogel Enabled by Strained Disulfide-Thiol Exchange and Core-Shell Thiolated Copolymer Nanoparticles for Efficient Hydrophobic Drug Delivery

• • Sustained release of hydrophobic drugs over 32 days in aqueous media, demonstrating prolonged therapeutic efficacy for chronic conditions. • • Rapid gelation under physiological conditions (PBS, pH 7.4) via strain-promoted disulfide-thiol exchange, enabling minimally invasive injection. • • Redox-responsive degradation under tumor-mimicking reducing conditions (e.g., 10 mM glutathione), facilitating triggered intracellular drug release. • • Excellent cytocompatibility and in vitro biodegradability, supporting clinical translation for localized drug delivery.