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Hydrogen-bond-mediated supramolecular polyhedra

Authors: CHEN Ran-Qi; LIU Feiyue; XING Yujie; WANG Jiayi; CHEN Aspen X.-Y.; WANG Yu; WU Huang

DOI: 10.1007/s40843-025-3568-4Status: Verified Translated Edition
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Key Findings in This Report

• • Encapsulation-induced stabilization of hydrogen-bonded heterocapsules achieves remarkable stability, as reported in Chem Eur J, 2013, 19: 3685–3692; this addresses the inherent dynamic lability of hydrogen bonds, enabling guest retention under ambient conditions for potential drug delivery and sensing applications. • • Guest rotation within self-assembled heterocapsules, demonstrated via Proc Natl Acad Sci USA, 2009, 106: 10444–10448, reveals rotational dynamics with correlation times on the nanosecond scale, critical for designing supramolecular gyroscopes and molecular machines with controlled motion. • • Mechanochemical encapsulation of fullerenes in peptidic containers via dynamic chiral self-sorting (Chem Eur J, 2016, 22: 3148–3152) achieves solvent-free inclusion with high selectivity, offering a scalable route for fullerene purification and functional materials without organic solvents. • • Hybrid hydrogen-bonded/metal-ligand coordination capsules enable dual control of guest exchange dynamics, with hemicapsular intermediates identified (Chem – An Asian J, 2014, 9: 1076–1082), providing a tunable platform for stimuli-responsive release and catalysis with precise kinetic regulation.