• • The p(AA-AuNCs) hydrogel, when combined with 1.00 V electrical stimulation, upregulates TGF-β, FGF-2, and EGF, promoting fibroblast proliferation, migration, and alignment—critical for accelerated wound healing.
• • The integrated zinc-ion battery delivers sustained, tunable electrical signals for over 7 days, enabling prolonged therapeutic intervention without external power sources.
• • In vivo application of the E-dressing achieves a 5-fold acceleration of wound closure and a 65.5% reduction in scar formation, demonstrating superior efficacy over conventional dressings.
• • The hydrogel maintains Col I/Col III balance and inhibits myofibroblast activation, directly addressing the molecular hallmarks of scar formation.