From Structural Chirality to Coined Biomedical Function: Recent Advances in Chiral Polyoxometalate-Based Materials

• • Chiral POMs exhibit enantioselective interactions with biomolecules, achieving up to 95% enantiomeric excess in recognition assays, which is critical for developing selective therapeutic agents. • • Photodynamic therapy augmented by chiral POM assemblies demonstrates a 3.2-fold increase in reactive oxygen species generation compared to achiral counterparts, enhancing anticancer efficacy. • • POM-based nanozymes mimic haloperoxidase activity, producing hypochlorous acid at concentrations sufficient to eliminate phagosomal bacteria with a minimum inhibitory concentration of 2.5 μg/mL. • • Chiral POMs inhibit amyloid β aggregation associated with Alzheimer's disease, reducing fibril formation by 80% at 10 μM concentration, as evidenced by Thioflavin T fluorescence assays.