Engineering an Ultrafast Gelling and Low Swelling Hyaluronic Acid Bioadhesive for Stable Wet-Tissue Adhesion and Enhanced Wound Healing

• • Ultrafast gelation: MPAH achieves gelation within 2 s under UV irradiation, outperforming commercial fibrin glues and enabling rapid sealing in clinical settings to mitigate hemorrhage and infection risks. • • Low swelling: Equilibrium swelling ratio below 30% in PBS over 16 days, preventing tissue compression and interfacial detachment, which is critical for maintaining adhesive integrity in wet, dynamic environments. • • Robust mechanical properties: Lap shear strength of ~35 kPa on wet porcine casings, extensibility exceeding 60%, and compressive strength of ~475 kPa, ensuring stable adhesion and mechanical reinforcement in moist tissues. • • Enhanced wound healing: In rat models, MPAH reduced inflammation and accelerated re-epithelialization compared to fibrin glue and sutures, demonstrating superior sealing and regenerative outcomes.