• • Manganese protoporphyrin liposomes achieved noninvasive immunogenic sonodynamic therapy against triple-negative breast cancer, inducing ICD without invasive procedures; this offers a clinical pathway for treating aggressive breast cancer subtypes with reduced systemic toxicity.
• • Acoustic-triggered nanobombs enabled ultrasound imaging-guided sonodynamic therapy and activated antitumor immunity, providing real-time imaging feedback and spatiotemporal control; this dual functionality addresses the need for precise, image-guided immunotherapy.
• • Mitochondrial-targeting liposomal nanosystems reinforced ICD via ultrasound-activated redox dyshomeostasis, achieving 9470–9491 Theranostics 2021 metrics; this demonstrates subcellular targeting to amplify immune activation, potentially overcoming resistance to conventional ICD inducers.
• • Catalase-based liposomes reversed immunosuppressive tumor microenvironment and enhanced chemo-photodynamic therapy, with Biomaterials 2020; this combination strategy tackles hypoxia-driven immunosuppression, a major barrier in solid tumors, improving therapeutic efficacy.