ElHyX: A Strain-Insensitive Elastomer-Hydrogel Biphasic Platform for Multimodal Implantable Bioelectronics

• • Strain-insensitive conductivity: EGaIn-SBS electrodes exhibit relative resistance change <5% over 1,000 cycles at 200% strain, ensuring reliable signal integrity under mechanical deformation. • • Durable wet-tissue adhesion: Ionic crosslinks in the hydrogel enhance adhesion on porcine skin, maintaining performance after swelling, critical for long-term implantation in dynamic physiological environments. • • Multimodal closed-loop operation: The integrated device simultaneously senses ECG, glucose, and heart rate, and triggers vagus nerve stimulation for insulin modulation, demonstrating autonomous therapeutic intervention in diabetic rats. • • Biocompatibility and stability: Long-term rodent implantation confirms favorable biocompatibility and stable working performance, supporting potential clinical translation for chronic disease management.