Electrospray Self-Healing Porous Polymer Microspheres for Multimode Imaging and Combined Photothermal/Chemodynamic Therapy of Nasopharyngeal Carcinoma

• • The PI-TAF@FN microspheres achieve a photothermal conversion efficiency of 51.4% under 808-nm laser irradiation, enabling effective photothermal ablation of NPC cells while minimizing off-target thermal damage. • • The microspheres exhibit an average size of 1.9 μm, which is optimal for intravenous administration and passive tumor accumulation via the enhanced permeability and retention effect, while maintaining colloidal stability for prolonged circulation. • • Heat-triggered self-healing of the porous PLGA matrix at the glass transition temperature enables controlled pore closure, preventing premature drug leakage and ensuring sustained release of ICG and TAF for combined therapy. • • The TAF metal-phenolic network provides both chemodynamic therapy via Fe3+-mediated Fenton reaction and T1-weighted magnetic resonance imaging contrast, enabling simultaneous therapeutic and diagnostic functions in a single platform.