Dimensionally Programmable Covalent Organic Frameworks via Reversible Coordination-Directed Clip-off Strategy and Its Application in Uranium Extraction

• • Reversible Ag–N coordination bonds with thiosulfate/Ag+ regulators enable dynamic COF dimensional programming, but long-term cyclic use incurs elevated material and operating costs due to silver consumption, directly impacting industrial economics for uranium recovery. • • Repeated cleavage and reconstruction of coordination bonds causes progressive structural fatigue, reducing cyclic stability after multiple cycles—a critical degradation mechanism that limits adsorbent lifespan in continuous wastewater treatment. • • Current validation remains at laboratory scale; column adsorption and continuous wastewater treatment require further exploration, with no reported breakthrough capacities or mass transfer coefficients to assess industrial feasibility. • • The strategy shows generalizability to other reticular frameworks including MOFs, enabling stimuli-responsive smart materials and adaptive separation membranes, but practical scalability demands optimization of regulating components and improved structural durability.