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Correction to: Gene Silencing-Mediated Immune Checkpoint Blockade for Tumor Therapy Boosted by Dendrimer-Entrapped Gold Nanoparticles

Authors: XUE Xue; LI Jin; FAN Yu; SHEN Mingwu; SHI Xiangyang

DOI: 10.1007/s40843-025-3609-0Status: Verified Translated Edition
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Key Findings in This Report

• • The original study demonstrated that dendrimer-entrapped gold nanoparticles (Au DENPs) enabled efficient siRNA delivery, achieving significant gene silencing and boosting immune checkpoint blockade, with tumor volume reductions showing statistical significance at p<0.01 and p<0.001. • • The correction ensures data integrity by rectifying a duplicated TUNEL staining image in Fig. 4d, which is critical for accurate interpretation of apoptosis induction in tumor tissues; the corrected image confirms the expected differences between treatment groups. • • The in vivo timeline and treatment protocol (n=6 per group) provide a reproducible framework for evaluating combination therapies, with relative tumor volume and body weight changes monitored over 14 days, offering benchmarks for future preclinical studies. • • The study's conclusions remain valid post-correction, underscoring the robustness of the Au DENP-based gene silencing approach for immune checkpoint blockade, which is relevant for developing targeted cancer immunotherapies.
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