Key Takeaways & Executive Findings
- •• • The correction addresses an image assembly error in Fig. 7a, which does not alter the study's conclusions; the toxicity data remain valid, with a single intravenous dose of 30 mg kg−1 CTX administered to CD-1 mice (n=5) and sacrifice on day 14. • • The toxicity assessment included H&E staining of major organs and CBC analysis, with statistical significance set at *p < 0.05; this ensures rigorous evaluation of potential hematological and histopathological effects. • • The study provides standard reference ranges for mouse CBC parameters (e.g., WBC: 0.8–6.8 × 10^9/L, RBC: 6.36–9.42 × 10^12/L, PLT: 450–1590 × 10^9/L), enabling precise interpretation of toxicity data. • • The correction maintains the integrity of the original research, which is critical for reproducibility and clinical translation of cabazitaxel-loaded nanoparticles prepared via lyophilization from dioxane.
Abstract
This correction addresses an image assembly error identified in Fig. 7a of the original article published in Science China Materials, volume 66, issue 6, 2023, pages 2513–2522. The error was confined to the assembly of images in Fig. 7a, which presents H&E staining analysis of major organs from a toxicity study. The corrected version of Fig. 7 is provided in this corrigendum. The original study evaluated the toxicity of lyophilized cabazitaxel (CTX) and Tween 80-based CTX formulations in CD-1 mice following a single intravenous administration of 30 mg kg−1 CTX via the tail vein on day 0, with sacrifice on day 14 for analysis (n=5). The figure includes H&E staining of major organs, complete blood count (CBC) analysis with statistical significance indicated by *p < 0.05, and mouse weight measurements. The correction does not affect the overall results, data interpretation, or scientific conclusions of the original article. All authors have reviewed and approved the content of this corrigendum. The authors sincerely apologize for any inconvenience caused to the editorial office, reviewers, and readers. The article was received on 6 May 2026, accepted on 4 June 2026, and published online on 31 July 2026.
1. Introduction
The original study focused on the facile preparation of cabazitaxel-loaded nanoparticles directly lyophilized from dioxane, addressing the need for stable and effective formulations of this poorly water-soluble chemotherapeutic agent. Conventional cabazitaxel formulations rely on Tween 80, which is associated with hypersensitivity reactions and requires premedication. The development of a lyophilized nanoparticle formulation aims to eliminate the need for Tween 80, thereby improving patient safety and convenience. The study evaluated the toxicity of the lyophilized formulation compared to the Tween 80-based formulation in a murine model, providing critical data on safety profiles.
This corrigendum corrects an image assembly error in Fig. 7a, which presented H&E staining results from the toxicity study. The error was limited to the assembly of images and did not affect the quantitative data or conclusions. The corrected figure ensures accurate representation of histopathological findings, which is essential for the scientific community to assess the safety of the formulation. The correction underscores the importance of meticulous data presentation in preclinical studies, as errors in figure assembly can undermine confidence in the results, even if the underlying data are sound.
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Boyang Sun, Shuai Shao, Sanjana Ghosh, Jiexin Li, Xiaojie Wang, Changning Li, Breandan Quinn, Paschalis Alexandridis, Jonathan F. Lovell, Yumiao Zhang (2026). Correction to: Facile preparation of cabazitaxel-loaded nanoparticles directly lyophilized from dioxane. SCIENCE CHINA Materials. https://doi.org/10.1007/s40843-026-4317-4
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Frequently Asked Questions
What was the specific error in Fig. 7a and how does it affect the interpretation of the toxicity data?
The error was an image assembly error in Fig. 7a, which displayed H&E staining of major organs. The correction provides the properly assembled figure. The error did not affect the overall results, data interpretation, or scientific conclusions of the original study. The toxicity data, including CBC analysis and mouse weights, remain valid.
What were the key toxicity parameters measured in the study, and what statistical significance was observed?
The study measured H&E staining of major organs, CBC parameters (e.g., WBC, RBC, PLT), and mouse weights. Data were analyzed via t-test, with *p < 0.05 considered statistically significant. The standard ranges for mouse CBC parameters were provided for reference.
How does the lyophilized CTX formulation compare to the Tween 80-based formulation in terms of toxicity?
The original study compared the toxicity of lyophilized CTX and Tween 80-based CTX formulations. The correction does not alter the findings, which indicated that the lyophilized formulation had a comparable safety profile to the Tween 80-based formulation, as assessed by H&E staining and CBC analysis.
What is the significance of using a lyophilized formulation for cabazitaxel?
Lyophilization from dioxane offers a facile method to produce stable nanoparticles of cabazitaxel without the need for Tween 80, which is associated with hypersensitivity reactions. This could improve patient safety and reduce the need for premedication, making the formulation more clinically attractive.
Are there any implications of this correction for future research or clinical translation?
The correction ensures that the published data are accurately represented, which is crucial for reproducibility and for building trust in the findings. The original conclusions remain unchanged, supporting the potential of lyophilized CTX nanoparticles as a viable alternative to Tween 80-based formulations. Future studies should continue to evaluate the efficacy and safety of this formulation in larger animal models and clinical trials.
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