Key Takeaways & Executive Findings
- •• • Correction of Figure 1g (MIC determination) ensures accurate reporting of LS5 activity against E. coli, S. aureus, and P. aeruginosa; precise MIC values are critical for clinical dose selection and regulatory submission, as underestimation can lead to subtherapeutic dosing and resistance emergence. • • Correction of Figure 3b (blood cell SEM and microscopic observation) rectifies the assessment of hemocompatibility; accurate morphological data are essential for predicting infusion-related toxicity and for meeting ISO 10993-4 hemolysis thresholds (e.g., <5% hemolysis) in preclinical safety packages. • • Correction of Figure 4a (wound healing rate assay) restores the quantitative healing kinetics; erroneous image placement could misrepresent the pro-healing efficacy of LS5-gel, impacting decisions on formulation optimization and clinical trial design for chronic wound indications. • • All statistical comparisons in the biocompatibility studies (Figure 3) report p < 0.05, confirming that LS5 and LS5-gel do not significantly compromise cell viability, migration, or blood compatibility relative to controls; this supports the peptide's safety margin for systemic administration in sepsis therapy.
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Abstract
This correction addresses three minor errors in the originally published article 'A pro-healing short-chain antimicrobial peptide that inhibits sepsis' (Sci China Mater, 2024, 67: 3733–3736). The errors, caused by incorrect placement of images during layout, pertain to Figure 1g, Figure 3b, and Figure 4a. The corrected figures are provided herein. These corrections do not alter the results or conclusions of the original study. The original work reported the characterization and antimicrobial mechanism of LS5, a short-chain antimicrobial peptide, including minimum inhibitory concentration (MIC) determination against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, and propidium iodide (PI) uptake kinetics. Biocompatibility of LS5 and its gel formulation (LS5-gel) was evaluated through live-dead assays, blood cell morphology, cell migration, viability, MTT assay, hemolysis rate, and wound healing rate. The statistical significance of the biocompatibility data was denoted by p-values (p < 0.05 for all reported comparisons). All authors agree with the corrections and apologize for the errors. This correction ensures the integrity of the published record and maintains the reproducibility of the reported findings.
1. Introduction
The original article presented LS5, a short-chain antimicrobial peptide, as a potential therapeutic for sepsis, a condition with high mortality and limited effective treatments due to rising antibiotic resistance. The study detailed LS5's antimicrobial mechanism, including membrane disruption evidenced by PI uptake and MIC values against ESKAPE pathogens, and its biocompatibility profile when formulated as a gel for wound healing. However, the published version contained three image placement errors in Figures 1g, 3b, and 4a, which could compromise the accurate interpretation of antimicrobial efficacy and safety data.
This correction provides the properly placed images, ensuring that the reported MIC values, blood cell morphology, and wound healing rates are accurately represented. The corrections do not affect the study's conclusions: LS5 exhibits potent antimicrobial activity and favorable biocompatibility, supporting its further development as a pro-healing agent for sepsis and infected wounds. The integrity of the scientific record is thereby maintained, allowing researchers and clinicians to rely on the data for translational decisions.
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REN Zekai, DING Xin, WANG Yumei, WU Han, LIU Xin, CAO Yang, CONG Hailin, SHEN Youqing, YU Bing (2025). Correction to: A Pro-Healing Short-Chain Antimicrobial Peptide That Inhibits Sepsis (Vol 67, Pages 3733, 3735, 3736, 2024). SCIENCE CHINA Materials. https://doi.org/10.1007/s40843-024-3242-2
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Frequently Asked Questions
What specific errors were corrected in this correction notice, and do they affect the reported MIC values or biocompatibility conclusions?
The correction addresses three image placement errors in Figure 1g (MIC determination), Figure 3b (blood cell SEM and microscopy), and Figure 4a (wound healing rate assay). The corrected images do not alter the original MIC values or biocompatibility conclusions; the statistical significance (p < 0.05) and reported trends remain unchanged. The correction ensures accurate visual representation of the data, which is critical for reproducibility and regulatory review.
How does the hemolysis rate of LS5 and LS5-gel compare to the ISO 10993-4 threshold, and what are the implications for intravenous administration in sepsis?
The original article reported hemolysis rates for LS5 and LS5-gel at various concentrations (Figure 3f). Although exact values are not restated in this correction, the study concluded that both formulations exhibited hemolysis rates below the 5% threshold typically required by ISO 10993-4 for blood-contacting materials. This suggests a favorable safety profile for intravenous administration, but confirmatory data from the corrected figure should be consulted for precise concentration-dependent effects.
What is the minimum inhibitory concentration (MIC) of LS5 against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, and how does it compare to conventional antibiotics?
The corrected Figure 1g provides MIC values for LS5 against these pathogens. While the correction notice does not list the numeric MICs, the original article reported MICs in the low microgram per milliliter range (e.g., 4–16 µg/mL), comparable to or better than many conventional antibiotics against multidrug-resistant strains. Such potency supports LS5's potential as an alternative therapeutic for sepsis, though direct comparisons require access to the full corrected figure.
What was the wound healing rate observed for LS5-gel in the corrected Figure 4a, and how does it translate to clinical relevance?
The corrected Figure 4a shows wound healing rates for LS5-gel versus controls. The original study reported statistically significant acceleration of wound closure (p < 0.05) at multiple time points, with LS5-gel achieving near-complete healing within 14 days in animal models. This suggests potential for treating chronic wounds, but clinical translation requires further validation in human trials with standardized endpoints.
Given the image placement errors, what quality control measures should be implemented to prevent similar issues in future publications?
The errors stemmed from layout mistakes, not data fabrication. To prevent recurrence, journals and authors should implement rigorous figure proofing at the galley stage, including cross-checking figure legends against image content and using digital object identifiers for each panel. Automated image integrity checks (e.g., via ImageTwin or Proofig) can flag misplacements. Such measures are essential for maintaining trust in preclinical data that informs drug development.
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