Collapsed nanomineral inducing oxidation-enhanced photoacoustic mechanical damage for elimination of solid tumor

• • PCSB nanomineral exhibits acid-responsive self-collapsing behavior, releasing therapeutic payloads specifically in tumor microenvironment (pH < 6.5), enhancing targeted delivery and reducing off-target toxicity. • • The combination of photoacoustic mechanical damage and SO2/Ca2+-induced oxidative stress achieves synergistic antitumor efficacy, overcoming tumor antioxidant defenses (e.g., GSH depletion) that limit conventional ROS-based therapies. • • In vivo studies demonstrate complete tumor elimination in murine models with a single treatment dose (10 mg/kg PCSB) and 808 nm laser irradiation (1.0 W/cm², 10 min), showing no recurrence over 30 days. • • The nanoplatform exhibits excellent biocompatibility, with negligible systemic toxicity (body weight change <5%) and high tumor accumulation (8.2% ID/g) as confirmed by photoacoustic imaging.