• • D-Mo-CDs exhibit a photothermal conversion efficiency (PCE) of 45.2% under 808 nm laser irradiation, which is 1.8-fold higher than that of L-Mo-CDs (25.1%), enabling effective photothermal killing of bacteria at low laser power densities (0.8 W/cm²).
• • Under left-handed circularly polarized light (LCP) irradiation, D-Mo-CDs generate 2.3-fold more reactive oxygen species (ROS) than L-Mo-CDs, as quantified by the DCFH-DA assay, leading to superior photodynamic antibacterial activity with a minimum inhibitory concentration (MIC) of 50 μg/mL against Staphylococcus aureus.
• • In vivo wound healing studies demonstrate that D-Mo-CDs + LCP treatment achieves 98.2% wound closure within 12 days, compared to 72.5% for the control group, with enhanced collagen deposition (measured by Masson's trichrome staining) and reduced inflammatory cytokine levels (TNF-α and IL-6) by 60% and 55%, respectively.
• • The chiral selectivity of D-Mo-CDs for LCP over RCP is quantified by a dissymmetry factor (g-factor) of 0.12 in circular dichroism (CD) spectra, enabling spatiotemporally precise activation only under the correct CPL handedness, thus minimizing off-target effects.