Chiral Supramolecular Helical Nanozymes with Tunable Screw Pitch and Catalytic Enantioselectivity

• • Screw pitch of P/M-DAIPA helical nanoribbons was precisely tuned from 360 nm to 3152 nm via alcohol-mediated self-assembly, enabling systematic control of chiral spatial asymmetry. • • P-DAIPA-Fe3O4 nanozyme exhibited higher catalytic efficiency toward S-DOPA, while M-DAIPA-Fe3O4 favored R-DOPA, demonstrating enantioselective catalysis. • • Catalytic enantioselectivity inversely correlated with screw pitch, with selectivity factors increasing from 1.52 to 2.01 as pitch decreased, indicating that tighter helical grooves enhance chiral discrimination. • • The enantioselectivity trend was also observed for R/S-tyrosinol oxidation, confirming the universal applicability of the pitch-dependent enantioselectivity across different substrates.