• • PDA@TEMPO nanozyme achieves sustained catalytic interception of lipid peroxyl radicals (ROO·) via a self-regenerating PCET cycle, overcoming stoichiometric exhaustion of conventional antioxidants.
• • The π-conjugated PDA framework enables electric-field-enhanced antioxidant response, dynamically accelerating radical interception under bioelectric fluctuations in a seizure model.
• • The nanozyme alleviates oxidative stress in neural microenvironments, as demonstrated in a seizure model, indicating potential for treating neurological disorders.
• • The design couples a PDA redox reservoir with TEMPO catalytic centers, establishing a general strategy for catalytic and sustained regulation of oxidative stress.