Bio-inspired barnacle cement nano-composite coating on biodegradable magnesium alloy for cerebrovascular application

• • The cp19k/NP@S-HA coating improves corrosion resistance of ZE21B Mg alloy by an average of 40.6% compared to uncoated alloy, as measured by electrochemical and static immersion tests, which is critical for delaying mechanical integrity loss in vivo. • • The coating significantly enhances endothelial cell proliferation and migration, key for rapid re-endothelialization and reducing thrombotic risk, while inhibiting smooth muscle cell proliferation and promoting contractile phenotype, thereby mitigating neointimal hyperplasia. • • The coating suppresses macrophage adherence and induces M2 phenotype polarization, reducing TNF-α expression and fibroplasia, which are central to modulating inflammatory responses and preventing restenosis. • • The dual-functional coating integrates the bioadhesive properties of barnacle cement protein cp19k with the anticoagulant and anti-inflammatory sulfonated hyaluronic acid nanoparticles, offering a synergistic approach for surface engineering of biodegradable stents.