Bio-camouflaged nanoreactors with spatiotemporally controlled Cu2+-Fenton catalysis for enhanced starvation-augmented mild photothermal therapy

• • The nanoplatform achieves spatiotemporal control of Cu2+-Fenton catalysis, enabling TME-responsive ·OH generation, which is critical for minimizing off-target toxicity in clinical translation. • • GOx-mediated glucose consumption elevates H2O2 and acidity, increasing Fenton reaction efficiency by >2-fold, as evidenced by enhanced ROS production in vitro. • • Mild photothermal therapy at 43–45°C synergizes with starvation to deplete ATP and inhibit HSP expression, overcoming tumor thermotolerance and improving therapeutic index. • • In vivo studies demonstrate significant tumor growth inhibition (tumor volume reduction >80%) with negligible systemic toxicity, highlighting the platform's clinical potential for TNBC.