• • Achieved 99.99% elimination of planktonic MRSA and 92.41% removal of mature biofilms in vitro, demonstrating near-complete bactericidal efficacy against resistant strains.
• • The Z-scheme heterojunction between UiO-66(Hf) and C70-COOH enhances piezoelectric response and charge separation, amplifying sonocatalytic ROS generation under ultrasound.
• • Fullerene's peroxidase-mimetic activity converts endogenous H2O2 into highly cytotoxic •OH, providing a second ROS pathway independent of external stimuli.
• • US-induced electron transfer from bacteria to U-B/F disrupts bacterial electron transport and energy metabolism, as confirmed by transcriptomic profiling, offering a non-ROS antibacterial mechanism.