• • MOGel+RT achieved an 80% tumor suppression rate in an orthotopic colon cancer model, demonstrating potent therapeutic efficacy.
• • The combination of MOGel and RT induced the strongest tumor cell apoptosis in vitro, indicating a synergistic effect.
• • MOGel alleviated tumor hypoxia via sustained oxygen release, counteracting RT-induced hypoxia that suppresses DC function.
• • Released bacterial outer membrane continuously activated DCs, enhancing antigen presentation and systemic anti-tumor immunity, as evidenced by an enhanced abscopal effect.