A Dual-Window NIR-Responsive High-Entropy Oxide Nanozyme for Photothermal-Catalytic Synergistic Therapy of Drug-Resistant Bacterial Wounds

• • The Fe-based high-entropy spinel oxide achieves photothermal conversion below 50 °C under dual-wavelength NIR-I/NIR-II irradiation, mitigating thermal damage to healthy tissue while maintaining bactericidal efficacy—a critical threshold for clinical translation in wound care. • • Peroxidase-like activity catalyzes H2O2 to generate abundant hydroxyl radicals (·OH), enabling synergistic antibacterial action that eradicates both Gram-positive and Gram-negative biofilms, addressing the polymicrobial nature of chronic wound infections. • • In a mouse model of drug-resistant bacterial wound infection, the material cleared infection, reduced inflammation, and promoted collagen deposition and angiogenesis, significantly accelerating wound healing under either NIR-I or NIR-II laser irradiation. • • The high-entropy effect induces lattice distortion and multiple metal d-orbital hybridization, cooperatively optimizing the electronic band structure to enable broad-spectrum NIR-I/NIR-II responsiveness—a design principle that overcomes the penetration-depth limitations of conventional NIR-I-only photothermal agents.