Prof. Yongsheng Li | Publications & Academic Profile | SinoGreenTech

Research Publications & English Decoded Briefs

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SCIENCE CHINA Materials•2026•DOI: 10.1007/s40843-026-4183-3

Ultra-sensitive ultraviolet organic photodetectors enabled by an expanded spectral window for health monitoring

Excessive ultraviolet (UV) radiation poses significant risks to human health, necessitating highly sensitive detection systems. Organic photodetectors (OPDs) offer high sensitivity and tunable spectral response, but their UV performance is constrained by conventional glass/indium tin oxide (ITO) substrates and electrodes, and insufficient photoactive layer responsivity. Here, we report high-performance UV-OPDs achieved through UV-transparent window and active-layer optimization. Replacing glass/ITO with a UV-transparent window comprising a quartz substrate and PH1000 electrode enhances UV transmittance. Integrating the high UV-responsive blend PM6:Y6:PC71BM as the active layer, the optimal ternary UV-OPD exhibits external quantum efficiency (EQE) exceeding 53% across 280–400 nm, with a peak EQE of 78.29% and responsivity of 214.68 mA/W at 340 nm, alongside a rapid response time of 2.6/2.1 μs. This performance represents the best combination of responsivity and response time reported to date in the UV region. We demonstrate the potential of these UV-OPDs for outdoor real-time UV monitoring. This work presents a promising strategy for developing high-performance UV-OPDs through transparent substrate and electrode engineering, and active-layer optimization.

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SCIENCE CHINA Materials•2025•DOI: 10.1007/s40843-025-3393-8

Dual-Locked SO2/Nanozyme Delivery Nanoplatform for Programmed Synergistic Gas/Chemodynamic Anticancer Therapy

SO2 gas therapy offers sustained assistance for augmenting the efficacy of ROS-based modalities due to its powerful tumor microenvironment-reversing capabilities. However, inefficient delivery and insufficient generation of SO2 have greatly limited the efficacy of SO2 therapy. Herein, we designed a programmed-responsive SO2/nanozyme synergistic therapeutic nanomedicine based on the polypeptide-type copolymer of poly(ethylene glycol)-b-poly(L-lysine) (PEG-b-PLL). By taking advantage of the abundant amine groups on the PLL blocks, a dual-locked SO2 releasing system was fabricated by grafting SO2 prodrug onto the PLL blocks through GSH-responsive covalent bonds and crosslinking the remaining amine groups with disulfide-connectors to form an outer stimulation-responsive shell. Such a dual encapsulation effectively prevented the premature release of SO2 in normal cells and guaranteed its timely and sustained release, making the SO2 therapeutic processes finely coordinate with the catalytic processes of nanozymes loaded in the micellar core. The well-matching of SO2 and nanozyme resulted in the efficacious remodeling of the tumor redox microenvironment, thus significantly enhancing the overall efficacy of chemodynamic therapy (CDT). This optimized multimodal cooperation strategy provides delicate control for improving the synergistic therapeutic efficiencies, which is anticipated to advance the ROS-based cancer treatments.

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