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Verified CAS / Academic Author2 Decoded Studies

Prof. Xu Ye

Nankai University

Research Publications & English Decoded Briefs

Showing 2 publications
SCIENCE CHINA Materials•2026•DOI: 10.1007/s40843-025-4024-1

Self-assembled theranostic nanoplatform-mediated calcium-overload for enhanced sonodynamic therapy

Sonodynamic therapy (SDT) faces limited efficacy due to robust antioxidant systems in tumors that scavenge reactive oxygen species (ROS). To overcome this, we developed a pH/ultrasound-responsive theranostic nanoplatform, Mn-CaCO3@NGQDs/PAA, via self-assembly of nitrogen-doped graphene quantum dots (NGQDs), Mn-doped CaCO3, and polyacrylic acid (PAA). This platform synergistically combines SDT with calcium overload. Under ultrasound irradiation, it generates abundant singlet oxygen (1O2), while the acidic tumor microenvironment triggers sustained Ca2+ release, inducing calcium overload. The combined effects amplify oxidative stress, suppressing tumor growth. Additionally, the nanoplatform exhibits dual-mode T1/T2-weighted magnetic resonance imaging (MRI) performance, enabling tumor localization. In vivo studies demonstrated significant tumor inhibition and apoptosis, with no notable toxicity. This integrated strategy maximizes therapeutic efficacy, offering a promising approach for enhanced tumor therapy.

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SCIENCE CHINA Materials•2025•DOI: 10.1007/s40843-025-3724-y

Amino-Modified Graphdiyne-Based Flexible Respiratory Sensor for Monitoring Sleep Apnea Syndrome

Respiratory sensors capable of real-time monitoring are essential for health management, disease prevention, and early diagnosis. Achieving real-time respiratory monitoring requires sensors with fast and sensitive response, high stability, and mechanical flexibility. Here, we demonstrate an amino-modified graphdiyne (NH2-GDY)-based sensor for real-time monitoring of human respiratory status. Compared to pristine graphdiyne, the amino-functionalized NH2-GDY exhibits enhanced adsorption capacity for water molecules. Its enlarged nanoporous structure facilitates the migration of water molecules, enabling rapid adsorption/desorption. The sensor demonstrates ultra-fast and ultra-sensitive respiratory responses, coupled with remarkable flexibility and stability. When integrated into a wearable electronic system, it achieves real-time monitoring of sleep apnea syndrome (SAS). This work highlights the feasibility of novel carbon-based respiratory sensors in advanced health monitoring applications. The sensor was fabricated on polyimide (PI) substrates, ensuring mechanical robustness. The amine-rich structure and nanoscale porosity of NH2-GDY facilitate rapid adsorption and transfer of water molecules, enabling fast and highly sensitive respiratory responses. This strategy provides a pivotal solution for early SAS diagnosis and disease management, establishing a novel respiratory sensing paradigm while expanding the application landscape of graphdiyne-based materials.

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