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WZ
Verified CAS / Academic Author2 Decoded Studies

Prof. WANG Zhuo

Institute of Semiconductors, Chinese Academy of Sciences

Co-Affiliations:Beijing University of Chemical Technology

Research Publications & English Decoded Briefs

Showing 2 publications
SCIENCE CHINA Materials2026DOI: 10.1007/s40843-025-3997-9

An Event-Driven Sensor Based on Colloidal Quantum Dots for Contactless Human-Machine Interaction

Contactless human-machine interaction (HMI) is rapidly evolving, yet it remains constrained by the latency, redundancy, and power consumption inherent in conventional frame-based vision sensors. While bio-inspired event-driven sensors offer a low-power alternative, existing architectures are often complex or fail to accurately encode the magnitude of light intensity changes. Herein, we report a solution-processed, two-terminal event-driven sensory device based on CuIn(Se,S)2 colloidal quantum dots (QDs) integrated with an Sb-doped TiO2 layer. Unlike traditional dynamic vision sensors (DVS), this device exhibits a transient photoresponse that encodes both the polarity and the magnitude of light intensity variations into the output current amplitude. This preservation of magnitude information significantly enhances the feature extraction capability, leading to faster convergence and superior clustering performance in gesture recognition. Based on these unique optoelectronic properties, we constructed a hierarchical HMI system that synergizes the strengths of event-based and frame-based sensing. The system utilizes the event-driven sensor for low-latency gesture control of an unmanned aerial vehicle (UAV) and a frame-based sensor for high-precision gaze control of an unmanned ground vehicle (UGV). The proposed system achieves a gesture recognition accuracy of more than 92.5% while substantially reducing data redundancy, offering a promising strategy for efficient, robust, and low-cost intelligent interaction systems.

SCIENCE CHINA Materials2026DOI: 10.1007/s40843-025-4081-y

Multifunctional mitochondria-targeting energy disruptor for enhancing imaging-guided low-temperature photothermal therapy of melanoma

The evolution of precision medicine has propelled multimodal imaging-guided phototheranostics to the forefront for precise tumor diagnosis and therapy. Low-temperature photothermal therapy (PTT) offers a promising approach for the treatment of melanoma due to its non-invasiveness and minimal damage to normal tissues. However, its efficacy is limited by cancer cell thermal tolerance. To address this, a new type of multifunctional energy disruptor (CAMeO-Q NPs) is developed featuring homologous targeting and mitochondria targeting, and synergistically enhancing low-temperature PTT in melanoma by reversing heat shock protein 90 (Hsp90)-mediated thermal tolerance and blocking mitochondrial adenosine triphosphate (ATP) biosynthesis. The multifunctional energy disruptor enables precise trimodal imaging (fluorescence imaging/FLI, photoacoustic imaging/PAI, and photothermal imaging/PTI) guidance for low-temperature PTT. Comprising a mitochondria-targeting photothermal agent and an Hsp90 inhibitor, CAMeO-Q NPs induce selective mitochondrial damage under 660 nm laser irradiation and downregulate cellular HSP expression by ATP inhibition and Hsp90 inhibitor. This multifunctional energy disruptor provides a novel strategy for enhancing multimodal imaging-guided low-temperature photothermal therapy through combined homologous targeting, mitochondria-targeting, and Hsp90 inhibition.