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Verified CAS / Academic Author2 Decoded Studies

Prof. REN Bin

Wuhan University School of Pharmaceutical Sciences

Co-Affiliations:Ningxia Highway and Bridge Construction Co., Ltd., Yinchuan 750016, China; Chang'an University, Xi'an 710061, China; Ningxia Hui Autonomous Region Highway and Waterway Engineering Quality Appraisal Center, Yinchuan 750002, China

Research Publications & English Decoded Briefs

Showing 2 publications
SCIENCE CHINA Materials•2026•DOI: 10.1007/s40843-026-4441-7

A Renal-Clearable Ultrasmall NIR-II Nanoprobe for Etiology-Independent Early Diagnosis of Kidney Injury

Early detection of kidney injury remains difficult because routine clinical indicators often lag behind tissue damage. Here we report uNP-CH1055, an ultrasmall renal-clearable NIR-II fluorescent nanoprobe for non-invasive imaging of kidney injury in vivo. uNP-CH1055 formed stable nanoparticles with a hydrodynamic diameter of 3.3 nm, showed good photostability, enabled low-background imaging under a 1200 nm long-pass filter, and underwent rapid renal clearance after intravenous administration. It also exhibited favorable biocompatibility in both cellular and animal studies. In three mechanistically distinct models of renal injury, cisplatin-induced acute kidney injury, ischemia–reperfusion injury and unilateral ureteral obstruction, renal fluorescence increased with injury severity and closely paralleled biochemical and histological indicators, including blood urea nitrogen, serum creatinine, KIM-1 and TUNEL-based readouts. These results identify uNP-CH1055 as a renal-clearable NIR-II probe for early and quantitative assessment of kidney injury across different pathological settings.

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Chinese Journal of Environmental Engineering•2026•DOI: 10.12030/j.cjee.202507095

Mechanical Properties and Microstructural Evolution of CO2-Mineralized Cured Steel Slag-Fly Ash Composite Cementitious Materials

This study investigates the optimization of CO2 mineralization curing on the performance of a ternary cementitious system comprising steel slag, fly ash, and Portland cement. Specimens were fabricated with varying residual water-to-cement ratios (r/w), steel slag and fly ash contents, curing pressures, and durations, then subjected to standard curing and CO2 mineralization curing. Compressive strength and carbon sequestration rate were measured, and X-ray diffraction (XRD) and scanning electron microscopy (SEM) were employed to analyze mineral composition and microstructural evolution. Results indicate that compressive strength first increases then rapidly decreases with increasing residual water-to-cement ratio, with an optimal r/w below 0.15. Both compressive strength and carbon sequestration rate increase with higher steel slag content; the 50% steel slag + 10% fly ash formulation exhibited the highest values. Microstructural analyses revealed that CO2 mineralization primarily consumes hydration products such as Ca(OH)2, C-S(Al)-H, and AFt, generating abundant calcium carbonate that densifies the pore structure, thereby enhancing mechanical properties. Lower residual water-to-cement ratios, higher steel slag content, or extended curing durations increase the content and crystallinity of calcium carbonate. SEM observations confirmed the presence of densely packed, well-crystallized rhombohedral calcite in specimens with lower water-to-cement ratios and higher steel slag content. These findings provide a mechanistic basis for the engineering application of CO2 mineralization curing in ternary solid-waste cementitious materials.

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