SCIENCE CHINA Materials•2026•DOI: 10.1007/s40843-026-4212-x
Idiopathic pulmonary fibrosis (IPF) is a lethal interstitial lung disease with limited therapeutic options. Current treatments, such as nintedanib and pirfenidone, target downstream fibrosis but fail to address the upstream drivers, including persistent alveolar epithelial injury and abnormal repair. This study presents an inhalable, reactive oxygen species (ROS)-responsive liposomal system (SAB/GC-1@Lip-cRGD) that co-delivers the antioxidant salvianolic acid B (SAB) and the thyroid hormone receptor β (TRβ) agonist Sobetirome (GC-1). The liposomes are surface-modified with cRGD peptides for targeted delivery to fibrotic lesions and possess a negative surface charge to enhance mucus penetration. In the high-ROS fibrotic microenvironment, the liposomes destabilize, releasing SAB and GC-1. SAB scavenges ROS to remodel the fibrotic niche, while GC-1 reactivates TRβ signaling, driving the differentiation of stalled Krt8+ transitional epithelial cells into functional alveolar type I (AT1) cells. In a mouse model of pulmonary fibrosis, SAB/GC-1@Lip-cRGD significantly reduced pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) and TGF-β1 in bronchoalveolar lavage fluid and lung homogenates. The proportion of CD206+ M2 macrophages decreased from 27.4% in the model group to 6.2% after treatment, indicating potent anti-inflammatory and anti-fibrotic effects. This synergistic strategy of microenvironment remodeling and epithelial regeneration achieved robust collagen depletion, restoration of alveolar integrity, and recovery of pulmonary function, outperforming single-drug or non-targeted formulations. The work provides a generalized paradigm for integrating microenvironment regulation with regenerative repair in pulmonary diseases.
Journal of Environmental Engineering Technology•2026•DOI: 10.13205/j.hjgc.202604001
This study systematically investigated the occurrence, spatial distribution, sources, and ecological risks of 160 pesticides in Dianchi Lake, a typical plateau lake impacted by agricultural activities. A total of 37 pesticides were detected in the water, with total concentrations ranging from 64.2 to 1132.8 ng/L (average 610.0 ng/L). Fungicides, including boscalid (BOS), fluopicolide (FPC), and dimethomorph (DMM), were dominant, contributing up to 65.0% of the total concentration. Spatially, the southern lake region exhibited significantly higher concentrations (672.5 ng/L) than the north, attributed to intensive facility agriculture. Highly hydrophobic pesticides, such as penconazole (PEN), showed a tendency to enrich in bottom layers. Source apportionment identified inflowing rivers and wastewater treatment plant effluents as primary input sources, with average concentrations 7 and 9 times higher than lake water, respectively. Ecological risk assessment revealed that pesticides posed the highest risk to algae, followed by daphnia and fish. Prometryn (PMT) was identified as a high-risk factor for algae, while profenofos (PFF) and carbendazim (CBD) posed potential threats to higher trophic levels. These findings provide fundamental data and technical support for understanding pesticide pollution in plateau lake ecosystems.
SCIENCE CHINA Materials•2025•DOI: 10.1007/s40843-025-3535-8
The brain's selective visual attention mechanism (SVAM) enables robust visual recognition in noisy environments through diverse neural action potential peaks acting as filters. Spiking neural networks (SNNs) mimic this paradigm but limited noise immunity and high write current density hinder brain-like efficiency. Hardware implementing SVAM necessitates spiking spintronic devices with noise-resistant and low operation current densities; such devices remain unreported. Here, we report an orbit-torque (OT) actuated ferromagnetic spiking synapse and neuron featuring a tunable peak action potential. These are more akin to biological neurons with varying sensitivities to external sensory stimuli, thereby augmenting the perception aptitude of the system in complex surroundings. Capitalizing on the high-efficiency OT, the ferromagnetic device demands a write current density of 5 × 10^6 A/cm^2, which is an order of magnitude lower than other spiking devices actuated by spin-orbit torque. Leveraging these neuromorphic devices, an all-spin SNN with low current density and tunable action potential peak has been fabricated, successfully mimicking the SVAM. In complex noise environment, the SNN achieves 92% on Cifar-10 and 95% on MNIST dataset, surpassing state-of-the-art spin-based SNNs by 5%. Our work provides a promising avenue for exploring the SVAM-inspired spiking neuromorphic devices, enhancing the bionic performance of the SNNs.